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Innovative technologies and active ingredients. Polynucleotide treatments are among the current trends in aesthetic medicine.
This treatment uses polynucleotides, which are natural DNA strands derived from salmon sperm. These substances are used to promote tissue regeneration and improve the condition of the skin. Unlike traditional fillers, it focuses on the overall quality of the skin.
Polynucleotides derived from salmon DNA are very similar to those found in our bodies, which is why they are well tolerated. After application, they help improve the appearance and condition of the skin. The result can be healthier, firmer, and more youthful-looking skin without the need for invasive procedures.
Polynucleotide treatments are among the biggest anti-aging trends of recent years—and for good reason. Clients often appreciate the natural-looking results without an artificial appearance, the quick recovery time, and the long-term improvement in skin quality. The treatment is suitable for both women and men who want to address the first signs of aging, as well as for those seeking an effective solution for problematic or irritated skin.
The procedure is performed on an outpatient basis. After applying an anesthetic cream, the product is gently introduced into the skin using mesotherapy needles. The procedure takes 30 to 45 minutes, and after treatment, the skin may be red with visible pimples, which will subside within 1 to 2 days.
The skin may appear firmer, more hydrated, and healthier. Its texture may improve, and fine lines may be less visible. The resulting effect is natural, without unwanted volume or a heavy feeling on the skin. The treatment is suitable even for delicate areas, such as the eye area or the lips.
This treatment is suitable for both women and men who are looking for a gentle yet effective method of skin rejuvenation without the need for invasive procedures or fillers. It is suitable for clients aged 25 and older who want to slow down the first signs of aging and support the skin’s natural regeneration.
It’s also ideal for sensitive, thin, or easily irritated skin that requires a gentle yet effective approach. This treatment can also help with skin care following acne or other damage. It is also suitable for those dealing with the aftereffects of inflammatory conditions or who want to improve their skin’s texture.
The risks and contraindications are similar to those of other injectable cosmetic procedures, such as the risk of minor bruising or mild irritation.
The entire process takes no more than 30 minutes. For maximum results, three sessions are recommended at intervals of 2 to 3 weeks, followed by a maintenance treatment after 1 year. Results are gradual. With each subsequent treatment, the skin may appear firmer and more radiant. Thanks to the short treatment time and minimal disruption to daily routines, this treatment is popular even among very busy clients.
The day before the procedure, we recommend that you avoid alcohol and caffeine and increase your fluid intake. For 24 hours after the treatment, we do not recommend wearing makeup, spending time in the sun, or using the sauna. We also recommend using special regenerative creams.
Salmon DNA does not have the same hydrating effect as hyaluronic acid, but it focuses on the overall health and condition of the skin. It does not absorb water, so it is also suitable for sensitive areas, such as around the eyes or lips, where unwanted volume is undesirable. If desired, these two methods can be combined, which will also provide hydration.
Like other products, this treatment is administered using the mesotherapy method, that is, through fine injections into the skin. Unlike standard mesotherapy solutions containing hyaluronic acid, however, it contains polynucleotides, which are associated with promoting tissue regeneration and improving skin quality. The result can be an improvement in the appearance and quality of the skin.
Yes, this treatment is often combined with other treatments, such as laser therapy, mesotherapy, or dermal fillers, though always based on the doctor’s individual assessment. Combining treatments can enhance and prolong the results.
The Dermaestet team attended a professional conference dedicated to biorevitalization using salmon DNA, a trend that is gaining popularity both worldwide and among our patients.


Polynucleotide treatment uses natural DNA strands extracted from salmon sperm. Unlike traditional fillers, it doesn’t just target the skin’s surface but helps improve the skin’s overall appearance and quality.
Polynucleotides are associated with improvements in skin quality and its overall appearance.
After applying an anesthetic cream, the product is administered into the skin using fine mesotherapy needles. The procedure takes 30 to 45 minutes. After the treatment, the skin may be red with visible bumps, which will subside within 1 to 2 days. For 24 hours after the procedure, makeup, sun exposure, and saunas are not recommended.
For maximum results, three sessions spaced 2 to 3 weeks apart are recommended, followed by a maintenance treatment after 1 year. With each subsequent application, the skin may appear firmer and more radiant. Thanks to the short treatment time and minimal disruption to daily routines, the treatment is popular even among very busy clients.
Polynucleotide treatment is suitable for both women and men aged 25 and older who want to slow down the first signs of aging or address sensitive, thin, or irritated skin. It is also suitable for post-acne skin care. Unlike hyaluronic acid, it does not produce a pronounced volumizing effect, but rather focuses on the overall appearance and condition of the skin.
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Directly in front of the clinic there is a spacious parking lot and bus stop No. 44 and 84 "Královopolská strojírna"