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We will be happy to discuss all options with you and find the most suitable solution for your needs.
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Directly in front of the clinic there is a spacious parking lot and bus stop No. 44 and 84 "Královopolská strojírna"
15 - 30 minutes
without anaesthesia
Rejuvenation with botulinum toxin is a proven method for reducing expression lines, particularly in the upper half of the face. It is most commonly used to smooth frown lines in the area between the eyebrows, known as the glabella. It also addresses horizontal “surprise” lines and wrinkles around the eyes. In cases of very deep wrinkles, it is often necessary to use a filler material for the affected area as well.
Here at Dermaestet, we use a highly diluted form of botulinum toxin, which is employed in many fields of modern medicine. Many myths and misconceptions have arisen around botulinum toxin due to misinterpretations and unprofessional use of this product. With us, you don’t have to worry about any of that. At our clinic, you’ll find not only top-notch specialists but also personalized care and a tailored solution to your specific concern.

Excessive sun exposure, smoking, and hormonal factors—all of these contribute to skin aging. Another factor is facial muscles, which, when contracted excessively, contribute to the formation of expression lines. The solution is the application of botulinum toxin, which is suitable for both women and men aged 18 and older. It is a proven method for getting rid of wrinkles while preventing them from deepening further.
Our experts can administer the treatment in a way that gives your face a youthful and natural appearance. We inject a very small dose of botulinum toxin into the target area, which then blocks the transmission of nerve signals to the muscle, causing it to stop moving. This effect is widely used in other fields of medicine to treat various neuromuscular disorders, as well as to reduce sweating—a popular treatment at Dermaestet among many clients.
During your initial consultation with our specialist, you will learn which treatments are suitable for your skin. For deeper wrinkles, we recommend the application of botulinum toxin combined with a filler, most commonly one based on hyaluronic acid. If you decide to proceed with the procedure, it can be performed during the consultation itself. Hyaluronic acid can be injected into the same area approximately 3 weeks after the botulinum toxin application, by which time the toxin has reached its full effectiveness.
This is a minimally invasive procedure that takes just a few minutes. Botulinum toxin is injected with a thin needle, known as an insulin pen, under the skin in the target area. The procedure is not painful; the injection feels like a pinch. A local anesthetic can also be used for your maximum comfort. We also recommend avoiding blood-thinning medications—such as Acetylsalicylic acid, Aspirin, etc.—at least on the day of the procedure.
You will notice the first changes in the treated area two to three days after the procedure, in the form of a slight stiffness. The full results of the procedure will be visible in 2 to 3 weeks. The skin will then appear visibly smoother, and wrinkles will either disappear or become less deep. After 4 to 6 months, the effects of botulinum toxin will gradually wear off. This is the time our body needs to restore neuromuscular transmission. After that, another application of botulinum toxin is possible. The advantage is that with subsequent applications, botulinum toxin can last up to 12 months. The reason for the prolonged effect is that once its effects wear off, the muscle’s ability to contract does not return to its original level.
Botulinum toxin administered by an experienced physician is safe, and side effects are rare. The most common side effects include temporary redness and a small bruise at the injection site, which resolve on their own within a few days. In rare cases, improper application technique may cause temporary drooping of the eyelid. That is why it is essential to entrust your care to experts with proven experience—such as the doctors at the Dermaestet clinic.
One of the biggest advantages of this procedure is that there is virtually no recovery time. You can resume your normal activities immediately after the treatment. For 4 hours following the procedure, it is advisable to avoid lying down, bending forward sharply, and touching the treated area. For 48 hours, we recommend limiting sports, alcohol consumption, sauna visits, cosmetic treatments, and exposure to strong sunlight.
Botulinum toxin and dermal fillers are two different treatments with distinct mechanisms of action. Botox relaxes muscle tension and is ideal for expression lines in the upper face. Hyaluronic acid-based fillers, on the other hand, add volume and smooth out deeper static wrinkles. For more pronounced wrinkles, we can combine these methods—we apply botulinum toxin first, and the filler can be added approximately 3 weeks later.
Botulinum toxin is suitable for both women and men aged 18 and older.
After application, wrinkles disappear completely, preventing them from deepening further; therefore, botulinum toxin is sometimes used preventively.
At our clinic, we use a botulinum toxin product in a highly diluted form that must meet strict regulatory standards. Botulinum toxin is used not only for wrinkle reduction but also in many other fields of modern medicine, such as correcting strabismus or treating neurological disorders. Many myths and misconceptions have arisen regarding botulinum toxin, partly due to unprofessional applications of this product. Our team consists of top experts with years of experience, so you have nothing to worry about here at Dermaestet.
After the application, we do not recommend the following activities for 4 hours: lying down, bending forward sharply, or touching the treated area, so that the botulinum toxin does not cause drooping of the eyelids or other complications. For 48 hours after the procedure, we do not recommend intense sun exposure, air travel, cosmetic skin treatments, massages, or drinking alcohol, which reduces the effectiveness of botulinum toxin.
After 4 to 6 months, the effects of botulinum toxin gradually wear off. This is the time our body needs to restore neuromuscular transmission. After that, re-treatment is possible.
With subsequent applications, botulinum toxin can last up to 12 months. The reason for this prolonged effect is that after the effects of botulinum toxin wear off, the muscle’s ability to contract does not return to its original level.
we have been taking care of you for 33 years
clients have undergone this procedure
Evaluation of the intervention
The consultation is free if you also undergo treatment during your visit.
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Directly in front of the clinic there is a spacious parking lot and bus stop No. 44 and 84 "Královopolská strojírna"